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CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.

CD137 engagement reduces follicular dendritic cell networks in a T cell-dependent manner. CD137 is a 39 kD TNF-receptor superfamily member also known as 4-1BB, TNFRSF9, Ly-63, and ILA (Induced by Lymphocyte Activation). CD137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. b CD137 mRNA expression in T-Rex/K-Ras cells incubated with various concentrations of IL-1α for 24 h. CD137 mRNA was measured by qTR-PCR. c CD137 mRNA expression in three human cancer cell lines incubated with 10 ng/mL IL-1α for 24 h.

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CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. 2020-10-20 · Background CD137 is a target for tumor immunotherapy.

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CD137 was originally discovered in 1989 and reported as a cell surface protein mainly located on activated T cells . CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development.

The biological activity is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90 % of inibition was seen using a concentration of 1 … CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4 + and CD 8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. 4-1BB (CD137, TNFRSF9) is a surface glycoprotein discovered by Kwon’s group as an activation antigen on the surface of T cells (Kwon and Weissman, 1989).Indeed, its regulated expression is induced upon CD3-TCR engagement and is further stimulated by CD28 ligation (Melero et al., 1998).Its expression is not confined to the T cell lineage since it is inducible on natural killer cells, B Entry name i: TNR9_HUMAN: Accession i: Q07011 Primary (citable) accession number: Q07011: Entry history i: Integrated into UniProtKB/Swiss-Prot: : February 1, 1995: Last sequence update: : February 1, 1995: Last modified: : April 7, 2021: This is version 184 of the entry and version 1 of the sequence. See complete history.: Entry status i: Reviewed (UniProtKB/Swiss-Prot): Annotation program 2013-12-19 The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways.
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CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family.

and CD137 were used. Isolation of CMV-specific CD8 + T cells using Dynabeads® Functionally active CMV-specific CD8 + T cells after isolation of CD137 + cells using Dynabeads® Fig 4: T cell lines expanded in vitro for 8 days with Human T-Activator CD3/CD28/CD137 express CD45RO, CD62L and were negative for CD57 indicating a central memory CD137 Antibody (BBK-2) is a high quality monoclonal CD137 antibody (also designated CD137 antibody) suitable for the detection of the CD137 protein of human origin.
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Recombinant Human CD137 Protein (Met1-Gln186) ECD 10041-H08H with a fusion His Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human CD137 protein for relevant bioassay and related research. CD137 is expressed on activated T cells, B cells, monocytes, and follicular dendritic cells.

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It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. Agonist monoclonal antibodies (mAb) to the immune costimulatory molecule CD137, also known as 4-1BB, are presently in clinical trials for cancer treatment on the basis of their costimulatory effects on primed T cells and perhaps other cells of the immune system. Here we provide evidence that CD137 is selectively expressed on the surface of tumor endothelial cells. Hypoxia upregulated CD137 on CD137-PE recognizes the CD137 (4-1BB) antigen, a 30 kDa glycoprotein of the tumor necrosis factor (TNF) receptor superfamily. CD137 is mainly expressed on activated CD4 and CD8 tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and T cells,inhibiting lymphocyte proliferation,activating apoptosis TNFRSF9 Phenotypes From GWAS Catalog for TNFRSF9 Gene CD137 is a costimulatory member of the TNF receptor superfamily that is expressed on a variety of immune cells following activation, including T cells, dendritic cells, and natural killer cells.

It is a member of the TNFR family and CD137 Antibody (BBK-2) is a monoclonal anti-CD137 antibody that detects human CD137 by WB, IP, IF and FCM. The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein 1 Jan 2021 Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune CD137, или TNFRSF9 — мембранный белок, рецептор из надсемейства рецепторов фактора некроза опухоли. У человека кодируется геном TNFRSF9.